They were attacked by the Creeper, with many of them being killed or taken.
In “Jeepers Creepers 2,” the Creeper targets a school bus carrying a high school basketball team and their cheerleaders. After the bus breaks down on a remote road, the Creeper picks off the students one by one. The creature is in the last days of its 23-day feeding cycle and is hunting for body parts to replace its own old or damaged ones. The students are terrorized and try to defend themselves, but the Creeper is relentless. Some students attempt to devise plans to fight back or escape, but their efforts are largely unsuccessful. The Creeper uses its ability to smell fear to identify which of the students it wants, indicating that it seeks specific body parts. By the end of the movie, only a few of the students survive the ordeal, with the Creeper retreating to hibernate for another 23 years after its feeding cycle ends.