Sheila Jackson, played by Joan Cusack, left the show in Season 5 after selling her home and deciding to travel the world with her new husband.
Sheila, a recurring character on the show “Shameless,” is introduced as the agoraphobic and kind-hearted mother of Karen Jackson. Throughout her time on the series, Sheila experiences significant character development, including overcoming her agoraphobia, engaging in various romantic relationships, and dealing with her daughter’s tumultuous life. Her departure from the show occurs after a series of events that lead her to seek a fresh start. In Season 5, Sheila marries Frank’s Native American friend, Sammy’s brother, and decides to leave her old life behind. She sells her house, which is a significant plot point since the Gallagher family had been using it for various purposes, including housing and financial gain. Her exit marks the end of Joan Cusack’s regular appearances on the show, although Sheila remains a beloved character among fans for her quirky personality and heartfelt moments.