George Lopez underwent a kidney transplant in 2005, which left him with a noticeable scar on his face. The surgery was necessary due to a genetic condition that caused his kidneys to deteriorate.
In more detail, George Lopez, the comedian and actor, has been open about his health struggles related to his kidneys. He was diagnosed with a genetic condition that caused his kidneys to fail. His then-wife, Ann Serrano, donated one of her kidneys to him, which saved his life. The transplant surgery was successful, but it left a scar on his lower neck, which is sometimes visible when he makes public appearances. This scar is often what people refer to when they notice something different about his face. Since the surgery, Lopez has been an advocate for kidney health and transplantation awareness, using his platform to educate others about the importance of organ donation.